Drug Complexation and Formulation of a Buccal Tablet

Formulation and Evaluation of Mucoadhesive Buccal Tablet of Simvastatin

In present study mucoadhesive buccal tablet of simvastatin was prepared. Solubility of Simvastatin was enhanced by complexing Simvastatin with β-CD in 1:2 molar concentrations. Six different formulations of tablets of Simvastatin containing the polymers in various combinations were prepared by direct compression method and characterized for swelling studies, % matrix erosion, surface pH, mucoad...

Ternary complexation of carvedilol, -cyclodextrin and citric acid for mouth-dissolving tablet formulation

Accepted March 11, 2009 The purpose of this study was to improve the solubility and dissolution rate of carvedilol by forming a ternary complex with b-cyclodextrin and citric acid and to formulate its mouth-dissolving tablets. The rationale for preparing mouth-dissolving tablet of carvedilol was to make the drug available in a soluble form in the mouth, which would facilitate its absorption fro...

Design, development and evaluation of pulsatile drug delivery system using tablet in tablet formulation

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...

formulation of nicotine buccal adhesive control release tablet for nicotine replacement therapy

Formulation and taste masking of Ranitidine orally disintegrating tablet

Orally Disintegrating Tablets (ODT) have the advantages of both solid dosage form specially the stability and ease of handling and liquid dosage forms including ease of swallowing and pre-gastric absorption. We focused on taste masking and formulation of ranitidine ODT which disintegrates rapidly in the mouth within 60 seconds using super-disintegrants, special polymers, water soluble and even ...